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Dead volume accounting Every vial has dead volume, the small amount of solution trapped below the needle tip when the vial appears empty

Claims about methylene blue are alluring, and its easy to buy into its promise

Unfortunately, as there is no clear guidance, consideration on a patient-by-patient basis is required

It is worth noting that the short half-life does not mean the benefits are equally short-lived

These can be signs of an early B12 deficiency or other nutritional deficiencies like folate, vitamin B2 (riboflavin), and vitamin B3 (niacin) deficiency

Medical supervision is required for correct preparation and dosing